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Charlotte is the largest city in North Carolina and the 20th largest in the United States, with a population of approximately 651,101 (2005 estimate). The Charlotte metropolitan area (MSA) had a 2006 estimated population of 1,594,799. As of 2005, CharlotteGastoniaSalisbury had a combined statistical area (CSA) population of 2,120,745. The city is at the center of one of the fastest growing metropolitan regions in the United States, with an average influx of roughly 20,000 newcomers into the region each year over the past decade. Charlotte is the county seat of Mecklenburg CountyGR6, and is located in southcentral North Carolina, near the South Carolina border. Nicknamed The Queen City (a moniker it shares with Cincinnati, Ohio), Charlotte was named in honor of Queen Charlotte, wife of King George III of England. After being driven out by the fierce opposition of the city's citizens to British occupation during the American Revolution, General Cornwallis wrote that Charlotte was "a hornet's nest of rebellion." A resident of Charlotte is referred to as a Charlottean (sharlatee'uhn).